What is NeuroPulse™ TPS® and how does .it work?

How does Alzheimer’s work?

Alzheimer’s disease is a protein misfolding disease caused by the accumulation of abnormally folded amyloid beta protein into amyloid plaques, and tau protein into neurofibrillary tangles in the brain.

These amyloid beta plaques cause programmed neuronal cell death. As these neurons die, it causes disruptions in the supply of blood to regions of the brain, affecting levels of oxygen, glucose and nutrients. Studies have shown Cerebral Blood Flow (CBF) to be on average 20% lower in people with Alzheimer’s compared to those without a neurodegenerative disease.

Alzheimer’s also affects the distribution of different neurotrophic factors such as the brain-derived neurotrophic factor (BDNF). BDNF acts on certain neurons of the central and peripheral nervous system, supporting survival of existing neurons, and encouraging growth and differentiation of new neurons and synapses. BDNF is essential to normal brain function, and reduced levels can lead to reduced cognitive abilities and depression.

What is NeuroPulse™ TPS®?

TPS® is an Alzheimer’s intervention which involves passing short acoustic pulses with an ultrasound frequency range through the patient’s head to stimulate deep cerebral regions of the brain with millimeter accuracy.

TPS® induces mechanotransduction, which is when cells convert mechanical stimulus into biochemical signals, stimulating growth factors such as BDNF. This not only improves cerebral blood flow, but also promotes the formation of new blood vessels (angiogenesis) and nerve regeneration. In addition it causes the release of nitric oxide (NO)5, which leads to direct vasodilation and improved blood circulation.

To perform the procedure, we use a machine called a Neurolith™, created by Storz Medical, one of Europe’s leading medical machine manufacturers since 1987.

What are the biological effects of Transcranial Pulse Stimulation (TPS®)?

  • Increase in cell permeability.
  • Stimulation of mechanosensitive ion channels.
  • Release of nitric oxide, which leads to vasodilation, increased metabolic activity and angiogenesis and has an anti-inflammatory effect.
  • Stimulation of vascular growth factors.
  • Stimulation of BDNF.
  • Migration and differentiation of stem cells.
patient undergoing transcranial pulse stimulation

Is Transcranial Pulse Stimulation (TPS®) Safe?

TPS® is a very safe procedure, thanks to the short duration of the TPS® stimulation, heating of the tissue is prevented. TPS® is performed directly through the skull, non-invasively. The patient remains awake during the treatment in a comfortable seated position. More than 1800 TPS® sessions have been performed using the Neurolith™ system since it’s first use for Alzheimer’s in 2018.

transcranial pulse stimulation diagram
transcranial pulse stimulation diagram 2

What are the Advantages of Treatment with TPS®?

  • Painless procedure
  • Minimal side effects
  • Non-invasive
  • No medication needed
  • No need to shave the hair
  • Personalised treatments based on MRI data
  • Remain in a comfortable seated position during treatment
  • Treatment sessions over just two weeks.
  • Promotes / prevents decline of cognitive capabilities with a 85% – 90% success rate

How do you measure improvement of symptoms?

One week after the treatment sessions have been completed, symptoms are assessed in a follow up consultation.

We measure the symptoms of Alzheimer’s using the CERAD scale. CERAD stands for the Consortium to Establish a Registry for Alzheimer’s Disease, and the test has been used by medical practitioners since 1986. It consists of a questionnaire with symptoms scored on a 4-point scale: normal, mild, moderate or severe impairment.

TPS® has been shown to significantly improve CERAD test performance and to reduce Beck’s Depression Index (BDI) score in patients with mild to moderate Alzheimer’s.

transcranial pulse stimulation graphs

The graphs above show cognitive improvements shown in participants of Beisteiner et al. (2020) which investigated the effectiveness of TPS® on patients with Alzheimer’s.

A. The global outcome for the patients cognitive state CERAD CTS (corrected total score), which improves significantly after TPS treatment

B. The CERAD logistic regression score (LR) also improved. LR focuses on tests important for AD type dementia.

C/D. Significant improvements were shown in memory and verbal functions.

E. Figural functions declined as they would have without treatment. This can be explained by the fact that brain areas involved in figural processing were not included in the treatment scheme in this study. This finding supports a specific treatment effect only found for stimulated networks.

If you have further questions about TPS®, or whether you or someone

.else may be eligible, contact one of our experts today for advice.

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neurolith tps machine